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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Jarrett S.G., Milder J.B., Liang L.-P., Patel M

[8] Managing gastrointestinal side effects is crucial for preventing electrolyte disturbances

This can include individuals who are sensitive to medication side effects, have experienced difficulty tolerating standard GLP-1 dose escalation, or are looking for a lower-intensity approach under medical supervision

Furthermore, both SM and exenatide selectively activated p38 MAPK phosphorylation in the spinal cord, providing additional evidence that SM exerts its anti-allodynic effects by targeting spinal GLP-1R and promoting microglial -endorphin synthesis via the p38 MAPK signaling cascade [72]